ORCID: 0000-0002-5392-9740

108. Miniaturized chemical tags for optical imaging.

Sam Benson, Fabio de Moliner, William Tipping, Marc Vendrell*

Angew. Chem. Int. Ed. 2022, 61, e202204788, doi: 10.1002/anie.202204788


107. A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies.

Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell* 

Nat. Commun. 2022, 13, 2366, doi: 10.1038/s41467-022-29691-w

(Protected in patent GB2108355.5)

(Follow-up funding from Scottish Enterprise to support spin-out formation).


106. Activatable fluorophores for imaging immune cell function

Lorena Mendive-Tapia, Marc Vendrell*

Acc. Chem. Res. 2022, 55, 1183-1193, doi: 10.1021/acs.accounts.2c00070


105. Rational design of Phe-BODIPY amino acids as fluorogenic building blocks for peptide-based detection of urinary tract Candida infections

Lorena Mendive-Tapia, David Mendive-Tapia, Can Zhao, Doireann Gordon, Sam Benson, Michael J. Bromley, Wei Wang, Jun Wu, Adelina Kopp, Lutz Ackermann*, Marc Vendrell*

Angew. Chem. Int. Ed. 2022, 61, e202117218, doi: 10.1002/anie.202117218

104. Effective penetration of a novel formulation of bleomycin through ex-vivo skin explants from two different species

Giulia Ferrari, Lisa Y. Pang*, Fabio De Moliner, Marc Vendrell, Richard J.M. Reardon, Andrew J. Higgins, Sunil Chopra, David J. Argyle

Cancers 2022, 14, 1083, doi: 10.3390/cancers14041083

(Featured in Special Issue 'Translational and Comparative Research on Innovative Anti-Cancer Therapies')


103. Rational design and synthesis of large Stokes shift 2,6-sulphur-disubstituted BODIPYs for cell imaging

Abigail E. Reese, Charles Lochenie, Ailsa Geddis, Luana A. Machado, Marcos C. de Souza, Flávia F.C. Marques, Carlos A. de Simone, Marcos M. Gouvêa, Leandro F. Pedrosa, Eufrânio N. da Silva Júnior*, Marc Vendrell*

Chemosensors 2022, 10, 19, doi: 10.3390/chemosensors10010019

(Featured in Special Issue 'Optical Materials: Synthesis and Biological Applications Symposium-XXXVIII Biennial Meeting RSEQ')

102. A bivalent activatable fluorescent probe for screening and intravital imaging of chemotherapy-induced cancer cell death

Nicole Barth, Lorena Mendive-Tapia, Ramon Subiros-Funosas, Ouldouz Ghashghaie, Rodolfo Lavilla, Laura Maiorino, Xue-Yan He, Ian Dransfield, Mikala Egeblad, Marc Vendrell*

Angew. Chem. Int. Ed. 2022, 61, e202113020, doi: 10.1002/anie.202113020

(Apotracker Red licensed and commercialised by BioLegend)

101. Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Fabio de Moliner, Ina Biazruchka, Karolina Konsewicz, Sam Benson, Suraj Singh, Jun-Seok Lee,* Marc Vendrell*

Front. Chem. Sci. Eng. 2022, 16, 128-135, doi: 10.1007/s11705-021-2080-8

(Featured in Special Issue on Molecular Sensors and Molecular Logic Gates)

100. Near-infrared fluorescent probes for the detection of cancer-associated proteases

Jamie I. Scott, Qinyi Deng, Marc Vendrell*

ACS Chem. Biol. 2021, 16, 1304-1307, doi: 10.1021/acschembio.1c00223

99. Chemodivergent manganese-catalyzed C–H Activation: modular synthesis of fluorogenic probes

Nikolaos Kaplaneris, Jongwoo Son, Lorena Mendive-Tapia, Adelina Kopp, Nicole Barth, Isaac Maksso, Marc Vendrell,* Lutz Ackermann*

Nat. Commun. 2021, 12, 3389, doi: 10.1038/s41467-021-23462

(Featured in Nature Communications Editors' Highlights: Organic Chemistry and Chemical Biology).

(Featured in Synform, 2021/11, A179–A182, doi: 10.1055/s-0040-1720540)


98. Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

Sam Benson, Fabio de Moliner, Antonio Fernandez, Erkin Kuru, Nicholas Asiimwe, Jun-Seok Lee, Lloyd Hamilton, Dirk Sieger, Isabel Ribeiro Bravo, Abigail Elliot, Yi Feng,* Marc Vendrell*

Nat. Commun. 2021, 12, 2369, doi: 10.1038/s41467-021-22578-2

(Protected in patent WO 2020/187913)

(Featured in 100+ news outlets. Altmetric Score > 1000, in the top 5% of all research outputs scored by Altmetric).

97. A palette of minimally-tagged sucrose analogues for real-time Raman imaging of intracellular plant metabolism

Fabio de Moliner, Kirsten Knox, Doireann Gordon, Martin Lee, William J Tipping, Ailsa Geddis, Anke Reinders, John M Ward, Karl Oparka, Marc Vendrell*

Angew. Chem. Int. Ed. 2021, 60, 7637-7642, doi: 10.1002/anie.202016802

(Featured in Synfacts by Dirk Trauner and Anna C. Impastato)

96. A functional chemiluminescent probe for in vivo imaging of Natural Killer cell activity against tumours

Jamie Scott, Sara Gutkin, Ori Green, Emily J. Thompson, Takanori Kitamura,* Doron Shabat,* Marc Vendrell*

Angew. Chem. Int. Ed. 2021, 60, 5699-5703, doi: 10.1002/anie.202011429

(Featured as Hot paper)

95. Genotype-phenotype map of an RNA-ligand complex

Olga Puchta, Grzegorz Sobczyk, Vanessa Smer-Barreto, Hollie Ireland, Marc Vendrell, Diego A. Oyarzún, Janusz M. Bujnicki, Graeme Whyte, Grzegorz Kudla*

BioRxiv 2020, doi: 10.1101/2020.12.17.423258

94. A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

Nicole Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario Shields, Jennifer Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix Goñi, Rodolfo Lavilla, John Marwick, Sonja Vermeren, Adriano Rossi, Mikala Egeblad, Ian Dransfield,* Marc Vendrell*

Nat. Commun. 2020, 11, 4027, doi: 10.1038/s41467-020-17772-7

(Protected in patent WO 2016/207626)

(Apo-15 licensed and commercialised as Apotracker Green by BioLegend)

​93. Fluorescent cyclic peptides for cell imaging

Lorena Mendive-Tapia,* Jinling Wang, Marc Vendrell*

Pep. Sci. 2020, e24181, doi: 10.1002/pep2.24181

(TOP downloaded article between 2019 and 2020)

92. Fluorescent amino acids as versatile building blocks for chemical biology

Zhiming Cheng, Erkin Kuru, Amit Sachdeva, Marc Vendrell*

Nat. Rev. Chem. 2020, 4, 275-290, doi: 10.1038/s41570-020-0186-z

(Featured in Front cover)

91. Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Ramon Subiros-Funosas, Vivian Cheuk Lam Ho, Nicole Barth, Lorena Mendive-Tapia, Morena Pappalardo, Xavier Barril, Ruoyu Ma, Chengbin Zhang, Bin-Zhi Qian, Miquel Sintes, Ouldouz Ghashghaei, Rodolfo Lavilla,* Marc Vendrell*

Chem. Sci. 2020, 11, 1368-1374, doi: 10.1039/C9SC05558D

(Featured among the most popular 2019-2020 analytical chemistry articles)

90. A fluorescent activatable AND-Gate chemokine CCL2 enables in vivo detection of metastasis-associated macrophages

Antonio Fernandez, Emily J. Thompson, Jeffrey W. Pollard, Takanori Kitamura,* Marc Vendrell*

Angew. Chem. Int. Ed. 2019, 58, 16894-16898, doi: 10.1002/ange.201910955

(Featured in 87 news outlets, including Google News). Highest Altmetric Score out of all time in Angewandte Chemie.

​89. Assessment of neutrophil apoptosis

Nicole D. Barth, Marc Vendrell, David A. Dorward, Adriano G. Rossi, Ian Dransfield*

Neutrophil: Methods and Protocols (Eds: Mark T. Quinn, Frank DeLeo), Methods in Molecular Biology, 2087, pp. 167-190 (2020), Springer Nature, doi: 10.1007/978-1-0716-0154-9_13

88. Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Peter Brown, RELISH Consortium, Yaoqi Zhou

Database 2019, 1-66, doi: 10.1093/database/baz085

87. BODIPY-labeled cyclobutanes by secondary C(sp3)-H arylations for live-cell imaging

Matteo Virelli, Wei Wang, Rositha Kuniyil, Jun Wu, Giuseppe Zanoni, Antonio Fernandez, Jamie Scott, Marc Vendrell, Lutz Ackermann*

Chem. Eur. J. 2019, 25, 12712-12718, doi: 10.1002/chem.201903461

(Featured as Hot Paper)


86. Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Zhi Ming Cheng, Wagner O. Valença, Gleiston G. Dias, Jamie Scott, Nicole D. Barth, Fabio de Moliner, Gabriela B. P. Souza, Richard J. Mellanby, Marc Vendrell,* Eufrânio N. da Silva Junior*

Bioorg. Med. Chem. 2019, 27, 3938-3946, doi: 10.1016/j.bmc.2019.07.017

(Featured in the special issue 'Chemical Immunology')

85. 3D bioprinting of mature bacterial biofilms for antimicrobial resistance drug testing

Evita Ning, Gareth Turnbull, Jon Clarke, Frederic Picard, Philip Riches, Marc Vendrell, Duncan Graham, Alastair Wark, Karen Faulds, Wenmiao Shu*

Biofabrication 2019, 045018, doi: 10.1088/1758-5090/ab37a0

84. In vivo tumor visualization through MRI off-on switching of NaGdF4–CaCO3 nanoconjugates

Zhigao Yi, Zichao Luo, Nicole D. Barth, Xianfu Meng, Hong Liu, Wenbo Bu, Angelo All, Marc Vendrell, Xiaogang Liu*

Adv. Mater. 2019, 1901851, doi: 10.1002/adma.201901851

83. Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model

Ahsan Akram, Nicolaos Avlonitis, Emma Scholefield, Marc Vendrell, Neil McDonald, Tashfeen Aslam, Thomas H. Craven, Calum Gray, David Collie, Andrew Fisher, Paul A. Corris, Timothy Walsh, Christopher Haslett, Mark Bradley, Kevin Dhaliwal*

Sci. Reports 2019, 9, 8422, doi: 10.1038/s41598-019-44804-0

82. A near-infrared probe for in vivo imaging of colorectal lesions in high-risk patients

Stephan Rogalla, Antonio Fernandez, Sanjiv S Gambhir, Marc Vendrell*

Gastroenterology 2019, 156, S376-S377, doi: 10.1016/S0016-5085(19)37785-6

81. SCOTfluors: small, conjugatable, orthogonal and tunable fluorophores for in vivo imaging of cell metabolism

Sam Benson, Antonio Fernandez, Nicole Barth, Fabio de Moliner, Mathew Horrocks, C Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Ziyuan Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell*

Angew. Chem. Int. Ed. 2019, 58, 6911-6915, doi: 10.1002/anie.201900465

(Protected in patent WO 2020/187919)

(Featured as Hot paper and in Angewandte Chemie Press Room)

(Featured in Synfacts by Dirk Trauner and Katharina Hull)

(TOP downloaded article in 2018-2019 Angewandte Chemie)

(Featured in 30+ news outlets. Highest Altmetric Score out of all inputs of similar age in Angewandte Chemie).

(SCOTfluors licensed and commercialised by Tocris)

​80. Fluorescent peptides for imaging of fungal cells

Can Zhao, Lorena Mendive-Tapia, Marc Vendrell*

Arch. Biochem. Biophys. 2019, 661, 187-195, doi: 10.1016/j.abb.2018.11.018

(Featured in special issue 'Peptides')

79. Fluorogenic peptides for the detection of programmed cell death

Ramon Subiros-Funosas, Nicole Barth, Jesus Sot, Felix Goni, Lorena Mendive-Tapia, Rodolfo Lavilla, Rodger Duffin, Adriano Rossi, Ian Dransfield, Marc Vendrell*

J. Pep. Sci. 2018, 24, S66-S67

 78. Tricarbocyanine N-triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo

Richard Mellanby,* Jamie Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell*

Chem. Sci. 2018, 9, 7261-7270, doi: 10.1039/C8SC00900G

(Protected in patent WO 2020/020905)

(Featured in The Herald, The Scotsman, The Press and Journal, UoE News)

77. Quinone-derived π-extended phenazines as new fluorogenic probes for live-cell imaging of lipid droplets

Fabio de Moliner, Aaron King, Gleiston G. Dias, Guilherme F. de Lima, Carlos A. de Simone, Eufrânio N. da Silva Júnior,* Marc Vendrell*

Front. Chem. 2018, 6, 339, doi: 10.3389/fchem.2018.00339

76. A remote control for switching

Marc Vendrell*

Nat. Chem. Biol. 2018, 14, 749-750, doi: 10.1038/s41589-018-0107-3

75. Multiple multicomponent reactions: unexplored substrates, selective processes and versatile chemotypes in biomedicine

Ouldouz Ghashghaei, Samantha Caputo, Miquel Sintes, Marc Revés, Nicola Kielland, Carolina Estarellas, F. Javier Luque, Anna Aviñó, Ramón Eritja, Ana Serna-Gallego, José Antonio Marrugal-Lorenzo, Jerónimo Pachón, Javier Sánchez-Céspedes, Ryan Treadwell, Fabio de Moliner, Marc Vendrell, Rodolfo Lavilla*

Chem. Eur. J. 2018, 24, 14513-14521, doi: 10.1002/chem.201802877

(Featured as Hot Paper)

74. Probing binding specificity of the sucrose transporter AtSUC2 with fluorescent coumarin glucosides

Fabio de Moliner, Kirsten Knox, Anke Reinders, John Ward, Paul McLaughlin, Karl Oparka,* Marc Vendrell*

J. Exp. Bot., 2018, 69, 2473-2482, doi: 10.1093/jxb/ery075

(Featured in Faculty of 1000)

73. A fluorescent activatable probe for imaging intracellular Mg2+

Ryan Treadwell, Fabio de Moliner, Ramon Subiros-Funosas, Toby Hurd, Kirsten Knox, Marc Vendrell*

Org. Biomol. Chem., 2018, 239-244, doi: 10.1039/c7ob02965a

(Featured in "Chemosensors and Molecular Logic" theme collection)

72. Quinone-based fluorophores for imaging biological processes

Gleiston G. Dias, Aaron King, Fabio de Moliner, Marc Vendrell,* Eufranio N. da Silva Junior*

Chem. Soc. Rev., 2018, 47, 12-27, doi: 10.1039/c7cs00553a

(Featured in the front cover of the 2018 Emerging Investigators Issue)

71. Fluorophore-drug conjugates to unravel the mechanisms of action of therapeutic assets

Antonio Fernandez, Marc Vendrell*

Biochemistry, 2018, 57, 175-176, doi: 10.1021/acs.biochem.7b00889

(Featured in the special issue 'Future of Biochemistry')

70. The 'phagocytic synapse' and clearance of apoptotic cells

Nicole Barth, John A. Marwick, Marc Vendrell, Adriano Rossi, Ian Dransfield*

Frontiers Immunol., 2017, 8, 1708, doi: 10.3389/fimmu.2017.01708

69. Chemical modulation of in vivo macrophage function with subpopulation-specific fluorescent prodrug conjugates

Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng,* Marc Vendrell*

ACS Cent. Sci., 2017, 3, 995-1005, doi: 10.1021/acscentsci.7b00262

​​68. On the synthesis of quinone-based BODIPY hybrids: new insights on antitumor activity and mechanism of action in cancer cells

Talita B. Gontijo, Rossimiriam P. de Freitas, Flavio S. Emery, Leandro F. Pedrosa, José B. Vieira Neto, Bruno C. Cavalcanti, Claudia Pessoa, Aaron King, Fabio de Moliner, Marc Vendrell*, Eufranio N. da Silva Júnior*

Bioorg. Med. Chem. Lett., 2017, 27, 4446-4456, doi: 10.1016/j.bmcl.2017.08.007

67. Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell imaging

Lorena Mendive-Tapia, Ramon Subiros-Funosas, Can Zhao, Fernando Albericio, Nick D. Read, Rodolfo Lavilla,* Marc Vendrell*

Nat. Protoc., 2017, 12, 1588–1619, doi: 10.1038/nprot.2017.048

66. A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Ramon Subiros-Funosas,  Lorena Mendive-Tapia,  Jesus Sot,  John Pound,  Nicole Barth,  Yaiza Varela,  Felix Goñi,   Margaret Paterson,  Christopher Gregory,  Fernando Albericio,  Ian Dransfield,  Rodolfo Lavilla,* Marc Vendrell*

Chem. Commun., 2017, 53, 945-948, doi: 10.1039/C6CC07879F

(Featured in "Biological Optical Imaging" theme collection)

65. Optical windows for imaging the metastatic tumour microenvironment in vivo

Takanori Kitamura, Jeffrey W. Pollard, Marc Vendrell*

Trends Biotechnol., 2017, 35, 5-8, doi: 10.1016/j.tibtech.2016.05.001

64. Modern synthetic avenues for the preparation of functional fluorophores

Fabio De Moliner, Nicola Kielland, Rodolfo Lavilla,* Marc Vendrell*

Angew. Chem. Int. Ed.., 2017, 56, 3758–3769, doi: 10.1002/anie.201609394

63. Selective detection of apoptotic vesicles with fluorescent Trp-BODIPY labelled cyclic peptides

Ramon Subiros-Funosas, Lorena Mendive-Tapia, John Pound, Jesus Sot, Felix M. Goni, Fernando Albericio, Rodolfo Lavilla, Marc Vendrell*

J. Pep. Sci., 2016, 22, S216.

62. Trp-BODIPY fluorogenic amino acids for minimally invasive labelling of peptides and enhanced live cell fluorescence imaging

Lorena Mendive-Tapia, Ramon Subiros-Funosas, Can Zhao, Ahsan R. Akram, Fernando Albericio, Nick D. Read, Rodolfo Lavilla, Marc Vendrell*

J. Pep. Sci., 2016, 22, S46.

​​61. Searching for the optimal fluorophore to label antimicrobial peptides

Can Zhao, Antonio Fernandez, Nicolaos Avlonitis, Greetje Vande Velde, Mark Bradley, Nick D. Read,* Marc Vendrell*

ACS Comb. Sci., 2016, 18, 689–696, doi: 10.1021/acscombsci.6b00081

(Featured in front cover)

60. Electrophilic, activation-free fluorogenic reagent for labeling bioactive amines

Miquel Sintes, Fabio De Moliner, David Caballero-Lima, David W. Denning, Nick D. Read, Nicola Kielland,* Marc Vendrell,* Rodolfo Lavilla*

Bioconjugate Chem., 2016, 27, 1430-1434, doi: 10.1021/acs.bioconjchem.6b00245

59. Combinatorial fluorophores for live cell imaging

Marc Vendrell*

Comb. Chem. High Throughput Screen., 2016, 19, 346, doi: 10.2174/138620731905160510213909

58. Red-​fluorescent activatable probes for the detection of hydrogen peroxide in living cells

Claudia Garcia-Guzman, Antonio Fernandez, Nicolaos Avlonitis, Mark Bradley, Marc Vendrell*

Comb. Chem. High Throughput Screen., 2016, 19, 353-361, doi: 10.2174/1386207319666160408151313

(Featured in front cover)

57. A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Liyun Zhang, Jun Cheng Er, Hao Jiang, Xin Li, Zhaofeng Luo, Thomas Ramezani, Yi Feng, Mui Kee Tang, Young-Tae Chang, Marc Vendrell*

Chem. Commun., 2016, 52, 9093-9096, doi: 10.1039/C6CC00095A

(Featured in Chem Comm Emerging Investigators Issue 2016)

56. Smart fluorescent probes for imaging macrophage activity

Antonio Fernandez, Marc Vendrell*

Chem. Soc. Rev., 2016, 45, 1182-1196, doi: 10.1039/C5CS00567A

(Featured in back cover)

55. Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue

Lorena Mendive-Tapia, Can Zhao, Ahsan R. Akram, Sara Preciado, Fernando Albericio, Martin Lee, Alan Serrels, Nicola Kielland, Nick D. Read, Rodolfo Lavilla,* Marc Vendrell*

Nat. Commun., 2016, 7, 10940-10948, doi: 10.1038/ncomms10940

(Protected in patent WO 2016/207626)

(Featured in 10+ news outlets)

54. Structural modifications of the antimicrobial peptide ubiquicidin for pulmonary imaging of bacteria in the alveolar space

Ahsan R. Akram, Nicolaos Avlonitis, Thomas Craven, Marc Vendrell, Neil McDonald, Emma Scholefield, Andrew Fisher, Paul Corris, Chris Haslett, Mark Bradley, Kevin Dhaliwal*

The Lancet, 2016, 387, S17, doi: 10.1016/S0140-6736(16)00404-9

53. Optically detectable antimicrobial peptides enable the immediate detection of bacteria and fungi in the lung

Ahsan R. Akram, Nicolaos Avlonitis, Marc Vendrell, Sunay Chankeshwara, Neil McDonald, Tashfeen Aslam, Emma Scholefield, Tim Walsh, Chris Haslett, Mark Bradley, Kevin Dhaliwal*

Thorax 2015, 70, A2–A3, doi: 10.1136/thoraxjnl-2015-207770.4

52. Multispectral phloem-mobile probes - properties and applications

Michael Knoblauch, Marc Vendrell, Erica de Leau, Andrea Paterlini, Kirsten Knox, Tim J Ross-Elliott, Anke Reinders, Stephen A. Brockman, John Ward, Karl Oparka*

Plant Physiol., 2015, 167, 1211-1220, doi: 10.1104/pp.114.255414

(Featured in Faculty of 1000)

51. A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D1 and D2 dopamine receptors

Anabel Molero, Marc Vendrell,* Jordi Bonaventura, Julian Zachmann, Laura López, Leonardo Pardo, Carme Lluis, Antoni Cortés, Fernando Albericio, Vicent Casadó, Miriam Royo*

Eur. J. Med. Chem., 2015, 97, 173-180, doi: 10.1016/j.ejmech.2015.04.052

50. A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells

Yogeswari Chandran, Nam-Young Kang, Sung-Jin Park, Samira Husen Alamudi, Jun-Young Kim, Srikanta Sahu, Dongdong Su, Jungyeol Lee, Marc Vendrell,* Young-Tae Chang*

Bioorg. Med. Chem. Lett., 2015, 25, 4862-4865, doi: 10.1016/j.bmcl.2015.06.037

(Protected in patent WO 2012/173575)

49. Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses

Sung-Jin Park, Hock Chuan Yeo, Nam-Young Kang, Hanjo Kim, Joyce Lin, Hyung-Ho Ha, Marc Vendrell, Jun-Seok Lee, Yogeswari Chandran, Dong-Yup Lee, Seong-Wook Yun, Young-Tae Chang*

Stem Cell Res., 2014, 12, 730-741, doi: 10.1016/j.scr.2014.03.002

48. Multicomponent reactions for de novo synthesis of BODIPY probes: in vivo imaging of phagocytic macrophages

Ana M. Vazquez-Romero, Nicola Kielland, Maria J. Arevalo, Sara Preciado, Richard J Mellanby, Yi Feng, Rodolfo Lavilla, Marc Vendrell*

J. Am. Chem. Soc., 2013, 135, 16018-16021, doi: 10.1021/ja408093p

(Featured in UB News)

47. Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin

Jun Cheng Er, Marc Vendrell, Mui Kee Tang, Duanting Zhai, Young-Tae Chang*

ACS Comb. Sci., 2013, 15, 452–457, doi: 10.1021/co400060b  

(Featured in front cover)

46. MegaStokes BODIPY-triazoles as environmentally-sensitive turn-on fluorescent dyes.

Jun Cheng Er, Mui Kee Tang, Chee Geng Chia, Huimin Liew, Marc Vendrell,* Young-Tae Chang*

Chem. Sci., 2013, 4, 2168-2176, doi: 10.1039/C3SC22166K

(Protected in patent WO 2014/104975)

45. Surface enhanced Raman scattering in cancer detection and imaging

Marc Vendrell,* Kaustabh Kumar Maiti,* Kevin Dhaliwal, Young-Tae Chang

Trends Biotechnol., 2013, 31, 249-257, doi: 10.1016/j.tibtech.2013.01.013

(Selected within the Top 25 Hottest Articles in 2013)

44. A fluorescent screening platform for the rapid evaluation of chemicals in reprogramming

Marc Vendrell, Sung-Jin Park, Yogeswari Chandran, Ken Chi-Lik Lee, Hyung-Ho Ha, Nam-Young Kang, Seong-Wook Yun, Young-Tae Chang*

Stem Cell Res., 2012, 9, 185-191, doi: 10.1016/j.scr.2012.06.006

43. Combinatorial Strategies in fluorescent probe development

Marc Vendrell,* Duanting Zhai, Jun Cheng Er, Young-Tae Chang*

Chem. Rev., 2012, 112, 4391-4420, doi: 10.1021/cr200355j

(Within the most read articles from Chemical Reviews in 2012)

42. Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production.

Jaoon Y.H. Kim, Jae Wook Lee, Woo Sirl Lee, Hyung-Ho Ha, Marc Vendrell, Jacqueline T. Bork, Youngsook Lee, Young-Tae Chang*

ACS Comb. Sci., 2012, 14, 395-398, doi: 10.1021/co300007a

41. Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride.

Nicola Kielland, Marc Vendrell, Rodolfo Lavilla,* Young-Tae Chang*

Chem. Commun., 2012, 48, 7401-7403, doi: 10.1039/C2CC32292G

40. Multiplex targeted in vivo detection of cancer using sensitive near-infrared SERS nanotags

Kaustabh Kumar Maiti, U. S. Dinish, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Sung Jin Park, Malini Olivo, Young-Tae Chang*

Nano Today, 2012, 7, 85-93, doi: 10.1016/j.nantod.2012.02.008

39. Synthesis of a novel BODIPY library and its application in the discovery of a fructose sensor

Duanting Zhai, Sung-Chan Lee, Marc Vendrell, Lai Peng Leong, Young-Tae Chang*

ACS Comb. Sci., 2012, 14, 81-84, doi: 10.1021/co200136b

(Most read articles from ACS Comb. Sci. in 2012)

38. Intracellular glutathione detection using MnO2-nanosheet-modified upconversion nanoparticles

Renren Deng, Xiaoji Xie, Marc Vendrell, Young-Tae Chang,* Xiaogang Liu*

J. Am. Chem. Soc., 2011, 133, 20168-20171, doi: 10.1021/ja2100774

37. Diversity-oriented optical imaging probe development

Jun-Seok Lee, Marc Vendrell, Young-Tae Chang*

Curr. Opin. Chem. Biol., 2011, 15, 760-767, doi: 10.1016/j.cbpa.2011.10.007

36. Solid-phase synthesis of BODIPY Dyes and development of an immunoglobulin fluorescent sensor

Marc Vendrell, Gaddamanugu Gopi Krishna, Krishna Kanta Ghosh, Duanting Zhai, Jun-Seok Lee, Qing Zhu, Yin Hoe Yau, Susana Geifman Shochat, Hyori Kim, Junho Chung, Young-Tae Chang*

Chem. Commun., 2011, 47, 8424-8426, doi: 10.1039/C1CC11774B

35. Combinatorial solid-phase synthesis of 6-aryl-1,3,5-triazines via Suzuki coupling

Jae Wook Lee, Hyung-Ho Ha, Marc Vendrell, Jacqueline T. Bork, Young-Tae Chang*

Aust. J. Chem., 2011, 64, 540-544, doi: 10.1071/CH11034

34. Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Marc Vendrell, Animesh Samanta, Seong-Wook Yun, Young-Tae Chang*

Org. Biomol. Chem., 2011, 9, 4760-4762, doi: 10.1039/C1OB05519D

(Protected in patent WO 2011/119114)

33. Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer imaging

Animesh Samanta, Kaustabh Kumar Maiti, Kiat-Seng Soh,  Xiaojun Liao, Marc Vendrell, U.S. Dinish, Seong-Wook Yun, Ramaswamy Bhuvaneswari, Hyori Kim, Shashi Rautela, Malini Olivo, Junho Chung, Young-Tae Chang*

Angew. Chem. Int. Ed. 2011, 50, 6089-6092, doi: 10.1002/anie.201007841

(Protected in patent WO 2011/119114)

(Featured in A*STAR Research)

32. A photostable near-IR protein labeling dye for in vivo imaging

Animesh Samanta, Marc Vendrell, Seong-Wook Yun, Zhenping Guan, Qing-Hua Xu, Young-Tae Chang*

Chem. Asian J.,  2011, 6, 1353-1357, doi: 10.1002/asia.201100041

(Protected in patent WO 2011/119114)

31. Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library

Jun-Seok Lee, Hyeong Kyu Kim, Suihan Feng, Marc Vendrell, Young-Tae Chang*

Chem. Commun., 2011, 47, 2339-2341, doi: 10.1039/C0CC04495D

30. Biotin ergopeptide probes for dopamine receptors

Marc Vendrell, Anabel Molero, Sergio Gonzalez, Kamil Pérez-Capote, Carme Lluis, Peter J. McCormick, Rafael Franco, Antoni Cortés, Vicent Casadó, Fernando Albericio, Miriam Royo*

J. Med. Chem., 2011, 54, 1080-1090, doi: 10.1021/jm101566d

29. Multiplex cancer cell detection by SERS nanotags with triphenylmethine and cyanine Raman reporters

Kaustabh Kumar Maiti, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Young-Tae Chang*

Chem. Commun., 2011, 47, 3514-3516, doi: 10.1039/C0CC05265E

28. Combinatorial search of sensors

Marc Vendrell, Suihan Feng, Young-Tae Chang*

Chemosensors: Principles, Strategies and Applications (Eds: Binghe Wang & Eric V. Anslyn), Wiley-WCH, pp 87-106 (2011), doi: 10.1002/9781118019580.ch6

27. Solid-phase synthesis of dyes and their application as sensors and bioimaging probes

Marc Vendrell, Hyung-Ho Ha, Sung Chan Lee, Young-Tae Chang*

Solid-Phase Organic Synthesis: Concepts, Strategies, and Applications (Eds: Patrick Toy & Yulin Lam), Wiley-WCH, pp. 427-440 (2011), doi: 10.1002/9781118141649.ch14

26. A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors

Aroa Soriano, Marc Vendrell, Sergio Gonzalez, Josefa Mallol, Fernando Albericio, Miriam Royo, Carmen Lluís, Enric I. Canela, Rafael Franco, Antoni Cortés, Vicent Casadó*

J. Pharmacol. Exp. Ther., 2010, 332, 876-885, doi: 10.1124/jpet.109.158824

25. Diversity-oriented fluorescence library approaches for probe discovery and development

Marc Vendrell, Jun-Seok Lee, Young-Tae Chang*

Curr. Opin. Chem. Biol., 2010, 14, 383-389, doi: 10.1016/j.cbpa.2010.02.020

24. A fluorescent rosamine compound selectively stains pluripotent stem cells

Chang-Nim Im, Nam Young Kang, Hyung Ho Ha, Xuezhi Bi, Jae Jung Lee, Sung-Jin Park, Sang Yeon Lee, Marc Vendrell, Yun Kyung Kim, Jun-Seok Lee, Jun Li, Young-Hoon Ahn, Bo Feng, Huck-Hui Ng, Seong-Wook Yun, Young-Tae Chang*

Angew. Chem. Int. Ed., 2010, 49, 7659-7662, doi: 10.1002/anie.201002463

(Featured in Chemical & Engineering News and in A-STAR Research)

23. Development of photostable near-infrared cyanine dyes

Animesh Samanta, Marc Vendrell, Rajkumar Das, Young-Tae Chang*

Chem. Commun., 2010, 46, 7406-7408, doi: 10.1039/C0CC02366C

(Protected in patent WO 2011/119114)

(Featured in Chem Inform)

22. Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors

Marc Vendrell, Aroa Soriano, Vicent Casadó, José Luis Díaz, Rodolfo Lavilla, Enric I. Canela, Carme Lluis, Rafael Franco, Fernando Albericio, Miriam Royo*

ChemMedChem, 2009, 4, 1514-1522, doi: 10.1002/cmdc.200900149

21. Diversity-oriented fluorescence library approach for the discovery of sensors and probes

Jun-Seok Lee, Yun Kyung Kim, Marc Vendrell, Young-Tae Chang*

Mol. Biosyst., 2009, 5, 411-421, doi: 10.1039/B821766C

(Featured in front cover)

20. Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe

Jun-Seok Lee, Nam-young Kang, Yun Kyung Kim, Hyeong Kyu Kim, Animesh Samanta, Suihan Feng, Marc Vendrell, Jung Hwan Park, Young-Tae Chang*

J. Am. Chem. Soc., 2009, 131, 10077-10082, doi: 10.1021/ja9011657

(Featured in JACS Select #10: Supramolecular and Chemical Cascade Approaches to Molecular Sensing).

19. Novel ergopeptides as dual ligands for adenosine and dopamine receptors

Marc Vendrell, Ester Angulo, Vicent Casadó, Carme Lluís, Rafael Franco, Fernando Albericio, Miriam Royo*

J. Med. Chem., 2007, 50, 3062-3069, doi: 10.1021/jm060947x

18. Multiple ligands applied to dopamine and adenosine receptors

Marc Vendrell, Ester Angulo, Aroa Soriano, Anabel Molero, Vicent Casadó, Carme Lluis, Rafael Franco, Sergi Ferre, Fernando Albericio, Miriam Royo*

Proceedings of the 5th Austrian-German-Hungarian-Italian-Polish-Slovenian Joint Meeting on Medicinal Chemistry. (Ed: Danijel Kikelj), 2007.

17. Multicomponent reactions with dihydroazines. Efficient synthesis of a diverse set of pyrido-fused tetrahydroquinolines

Inés Carranco, José Luis Díaz, Óscar Jiménez, Marc Vendrell, Fernando Albericio, Miriam Royo, Rodolfo Lavilla*

J. Comb. Chem., 2005, 7, 33-41, doi: 10.1021/cc049877a

(Most accessed articles in J. Comb. Chem. 2005)

16. N-[Chloro(dimethylamino)methylene]-N-methylmethanaminium chloride (TMUCl Cl), the reagent of choice for the solid-phase synthesis of anilides

Marc Vendrell, Rubén Ventura, Ariel Ewenson, Miriam Royo, Fernando Albericio*

Tet. Lett., 2005, 46, 5383-5386, doi: 10.1016/j.tetlet.2005.05.140

15. A re-evaluation on the use of Rink, BAL and PAL resins and linkers

Francesc Yraola, Rubén Ventura, Marc Vendrell, Aina Colombo, Joan-Carles Fernández, Natalia de la Figuera, Dolors Fernández-Forner, Miriam Royo, Pilar Forns, Fernando Albericio*

QSAR Comb. Sci., 2004, 23, 145-152, doi: 10.1002/qsar.200420013

14. Minimalism applied to a hit to lead program

Marc Vendrell, Rubén Ventura,  Fernando Albericio, Rosario González-Muñiz, Laura García de Diego, Cristina Carreño, Antonio Ferrer-Montiel, Miriam Royo*

Peptide Revolution: Genomics, Proteomics & Therapeutics. 18th American Peptide Symposium (Eds: Michael Chorev & Tomi K. Sawyer), 2003.

13. Is it possible to minimize the toxicity of a hit compound without reducing its activity?

Rubén Ventura, Marc Vendrell, Fernando Albericio, Rosario González-Muñiz, Laura García de Diego, Cristina Carreño, Antonio Ferrer-Montiel, Miriam Royo*

Peptide Revolution: Genomics, Proteomics & Therapeutics. 18th American Peptide Symposium (Eds: Michael Chorev & Tomi K. Sawyer), 2003.


12. Antifungal therapeutic and diagnostic compounds in relation to fungal keratitis

Can Zhao, Michael J. Bromley, Marc Vendrell et al.

GB priority file 2109478.4 (2021)

11. Molecular probes for granzyme B detection

Marc Vendrell, Jamie Scott, Doireann Gordon

GB priority file 2108355.5 (2021)

10. Small molecule photosensitizers for photodynamic therapy

Marc Vendrell, Sam Benson, Antonio Fernandez, Fabio de Moliner, Nicole Barth

​WO 2020/187913 (granted in EU and USA)

9. Small tunable fluorophores for the detection and imaging of biomolecules

Marc Vendrell, Sam Benson, Antonio Fernandez, Fabio de Moliner, Nicole Barth

​WO 2020/187919 (granted in EU and USA)


8. Near-infrared chromophores, process of preparation and methods of use

Marc Vendrell, Antonio Fernandez, Richard Mellanby, Jamie Scott, Iris Mair, Claudia Garcia-Guzman, Baljean Dhillon, Pierre Bagnaninchi

WO 2020/020905

7. Molecular probes for detecting gram-negative bacteria in vitro and in vivo

Mark Bradley, Annamaria Lillenkampf, Nicolaos Avlonitis, Marc Vendrell, Neil McDonald, Chris Haslett, Kev Dhaliwal, Tim Walsh

WO 2016/075483 (granted in USA, Japan, Canada, India)

6. Fluorescent polybranched probes for detecting bacteria and/or fungi in vitro and in vivo

Mark Bradley, Annamaria Lillenkampf, Nicolaos Avlonitis, Marc Vendrell, Neil McDonald, Chris Haslett, Kev Dhaliwal, Tim Walsh

WO 2016/075484 (granted in EU, USA, Japan, Canada, India)


5. Fluorogenic amino acid derivatives, process of preparation thereof and methods of use

Marc Vendrell, Ramon Subiros-Funosas, Rodolfo Lavilla, Lorena Mendive-Tapia, Fernando Albericio, Nick Read

WO 2016/207626

4. Megastokes amino-triazolyl-BODIPY compounds and applications to live neuron staining and human serum albumin FA1 drug site probing

Young-Tae Chang, Jun Cheng Er, Cheryl Kit Mun Leong, Seong-Wook Yun, Marc Vendrell, Mui Kee Tang

WO 2014/104975 (granted in China, USA, Japan, EU, Korea, Singapore)

3. Alkylamino BODIPY dyes as selective fluorescent probes for proteins and mouse embryonic stem cells

Young-Tae Chang, Marc Vendrell, Duanting Zhai, Nam-Young Kang, Yogeswari Chandran

WO 2012/173575 (granted in EU, USA)

2. New cyanine dye used for labeling biomolecule e.g. protein and peptide, detecting presence of target in sample and functionalizing nanoparticles in biosensor

Young-Tae Chang, Animesh Samanta, Marc Vendrell, Nam-Young Kang, Kaustabh Kumar Maiti, Kiat-Seng Soh, U.S. Dinish, Malini Olivo, Sung Jin Park

WO 2011/119114 (granted in EU)

1. Pyrrolopyrimidine derivatives as JAK3 inhibitors

Jorge Solanas, Carmen Almansa, Robert Soliva, Montserrat Fontes, Marc Vendrell

WO 2008/119792 (granted in China, Israel, Australia, Canada, Korea, Mexico, EU, India, Russia, USA)