DYNAFLUORS
TM
Dynamic
Fluorophores
Activatable
127. No-wash fluorogenic labeling of proteins for reversible photoswitching in live cells
Kenji Torii, Sam Benson, Yuichiro Hori,* Marc Vendrell,* Kazuya Kikuchi*
Chem. Sci. 2024, doi: 10.1039/D3SC04953A
Abigail E Reese, Fabio de Moliner, Lorena Mendive-Tapia, Sam Benson, Erkin Kuru, Thomas Bridge, Josh Richards, Jonathan Rittichier, Takanori Kitamura, Amit Sachdeva, Henry J McSorley, Marc Vendrell*
ACS Cent. Sci. 2023, doi: 10.1021/acscentsci.3c01125
125. Imaging proteins sensitive to direct fusions using transient peptide–peptide interactions
Zoe Gidden, Curran Oi, Emily J Johnston, Zuzanna Konieczna, Haresh Bhaskar, Lorena Mendive-Tapia, Fabio de Moliner, Susan J Rosser, Simon GJ Mochrie, Marc Vendrell, Mathew H Horrocks,* Lynne Regan*
ACS Nano Lett. 2023, 23, 10633-10641, doi: 10.1021/acs.nanolett.3c03780
124. Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice
Katia Monsorno, Kyllian Ginggen, Andranik Ivanov, An Buckinx, Arnaud L. Lalive, Anna Tchenio, Sam Benson, Marc Vendrell, Angelo D’Alessandro, Dieter Beule, Luc Pellerin, Manuel Mameli, Rosa Chiara Paolicelli*
Nat. Commun. 2023, 14, 5749, doi: 10.1038/s41467-023-41502-4
123. Fluorescent Probes for Imaging in Humans: Where Are We Now?
Deborah Seah, Zhiming Cheng and Marc Vendrell*
ACS Nano 2023, 17, 19478-19490, doi: 10.1021/acsnano.3c03564
122. Smart probes for optical imaging of T cells and screening of anti-cancer immunotherapies
Marco Bertolini Man Sing Wong, Lorena Mendive-Tapia and Marc Vendrell*
Chem. Soc. Rev. 2023, 52, 5352-5372, doi: 10.1039/D2CS00928E
(Featured Inside Front Cover)
121. Environmentally sensitive photosensitizers enable targeted photodynamic ablation of Gram-positive antibiotic resistant bacteria
Sam Benson,* Alex Kiang, Charles Lochenie, Navita Lal, Syam Mohan P. C. Mohanan, Gareth O. S. Williams, Kevin Dhaliwal, Bethany Mills,* Marc Vendrell*
Theranostics 2023, 13, 3814-3825, doi: 10.7150/thno.84187
120. Charting the chemical reaction space around a multicomponent combination: controlled access to a diverse set of biologically relevant scaffolds
Pau Nadal-Rodriguez, Ouldouz Ghashghaei, Anna M Schoepf, Sam Benson, Marc Vendrell, Rodolfo Lavilla*
Angew. Chem. Int. Ed. 2023, e202303889, doi: 10.1002/anie.202303889
119. Late-stage peptide labeling with near-Infrared fluorogenic nitrobenzodiazoles by manganese-catalyzed C–H activation
Tsuyoshi Oyama, Lorena Mendive-Tapia, Verity Cowell, Adelina Kopp, Marc Vendrell,* Lutz Ackermann*
Chem. Sci. 2023, 14, 5728-5733, doi: 10.1039/D3SC01868G
118. Does the metastatic immunoenvironment determine poor immunotherapy responses?
Nicole D Barth, Floris J van Dalen, Camille Duran, Utsa Karmakar, Lorena Mendive-Tapia, Takanori Kitamura, Martjin Verdoes, John S Condeelis, Maja Oktay, Marc Vendrell, Valerie Brunton, David Entenberg
Cancer Res. 2023, 83, 3591, doi: 10.1158/1538-7445.AM2023-3591
117. Acid-resistant BODIPY amino acids for peptide-based fluorescence imaging of GPR54 receptors in pancreatic islets.
Lorena Mendive-Tapia,* Laia Miret-Casals, Nicole D. Barth, Jinling Wang, Anne de Bray, Massimiliano Beltramo, Vincent Robert, Christophe Ampe, David J. Hodson, Annemieke Madder, Marc Vendrell*
Angew. Chem. Int. Ed. 2023, e202302688, doi: 10.1002/anie.202302688
(Featured as HOT paper)
116. Release of immunomodulatory peptides at bacterial membrane interfaces as a novel strategy to fight microorganisms
Thiago Viana de Freitas, Utsa Karmakar, Andreanne G. Vasconcelos, Michele A. Santos, Bianca Oliveira do Vale Lira, Samuel Ribeiro Costa, Eder Alves Barbosa, José Cardozo-Fh, Rafael Correa, Dalila J. S. Ribeiro, Maura Vianna Prates, Kelly G. Magalhães, Marcelo Henrique Soller Ramada, José Roberto de Souza Almeida Leite, Carlos Bloch Jr, Aline Lima de Oliveira, Marc Vendrell, Guilherme Dotto Brand*
J. Biol. Chem. 2023, 299, 103056, doi: 10.1016/j.jbc.2023.103056
115. Fluorogenic granzyme A substrates enable real-time imaging of adaptive immune cell activity
Zhiming Cheng, Emily J Thompson, Lorena Mendive-Tapia, Jamie I Scott, Sam Benson, Takanori Kitamura, Ana Senan-Salinas, Youhani Samarakoon, Edward W Roberts, Maykel A Arias, Julian Pardo, Eva M Galvez, Marc Vendrell*
Angew. Chem. Int. Ed. 2023, e202216142, doi: 10.1002/anie.202216142
(Featured as HOT paper)
(Featured in the Angewandte Hot Topic: Tumours and Cancer)
114. Small fluorogenic amino acids for peptide-guided background-free imaging
Fabio de Moliner, Zuzanna Konieczna, Lorena Mendive-Tapia, Rebecca S. Saleeb, Katie Morris, Juan Antonio Gonzalez-Vera, Takeshi Kaizuka, Seth G. N. Grant, Mathew H. Horrocks,* Marc Vendrell*
Angew. Chem. Int. Ed. 2023, 62, e202216231, doi: 10.1002/anie.202216231
(Featured as HOT paper)
113. A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging
Antonio Fernandez,* Nicola Kielland, Ashraff Makda, Neil O. Carragher, M. Carmen González-García, Laura Espinar-Barranco, Juan A. González-Vera, Angel Orte, Rodolfo Lavilla, Marc Vendrell*
RSC Chemical Biology, 2022, 3, 1251-1259, doi: 10.1039/d2cb00168c
112. Enzyme-activatable chemokine conjugates for in vivo targeting of tumor-associated macrophages
Nicole D. Barth, Floris J. van Dalen, Utsa Karmakar, Marco Bertolini, Lorena Mendive-Tapia, Takanori Kitamura, Martijn Verdoes,* Marc Vendrell*
Angew. Chem. Int. Ed. 2022, 61, e202207508, doi: 10.1002/anie.202207508
(Featured as HOT paper)
(Featured as a Research Highlight in Nature Reviews Chemistry, doi: 10.1038/s41570-022-00435-0)
111. Phototherapeutic induction of immunogenic cell death and CD8+ T cell-granzyme B mediated cytolysis in human lung cancer cells and organoids
Asta Valanciute,* Layla Mathieson, Richard A. O’Connor, Jamie I. Scott, Marc Vendrell, David A. Dorward, Ahsan R. Akram, Kevin Dhaliwal*
Cancers 2022, 14, 4119, doi: 10.3390/cancers14174119
110. A brain atlas of synapse protein lifetime across the mouse lifespan
Edita Bulovaite, Zhen Qiu, Maximilian Kratschke, Adrianna Zgraj, David G. Fricker, Eleanor J. Tuck, Ragini Gokhale, Babis Koniaris, Shekib A. Jami, Paula Merino-Serrais, Elodie Husi, Lorena Mendive-Tapia, Marc Vendrell, Thomas J. O’Dell, Javier DeFelipe, Noboru H. Komiyama, Anthony Holtmaat, Erik Fransén, Seth G. N. Grant*
Neuron, 2022, 110, 4057-4073 , doi: 10.1016/j.neuron.2022.09.009
109. Triazole-derivatized near-infrared cyanine dyes enable local functional fluorescent imaging of ocular inflammation
Chloe N. Thomas,* Nada Alfahad, Nicholas Capewell, Jamie Cowley, Eleanor Hickman, Antonio Fernandez, Neale Harrison, Omar S. Qureshi, Naomi Bennett, Nicholas M. Barnes, Andrew D. Dick, Colin J. Chu, Xiaoxuan Liu, Alastair K. Denniston, Marc Vendrell, Lisa J. Hill*
Biosens. Bioelect. 2022, 216, 114623, doi: 10.1016/j.bios.2022.114623
(Featured in UniBirmingham News)
108. Miniaturized chemical tags for optical imaging
Sam Benson, Fabio de Moliner, William Tipping, Marc Vendrell*
Angew. Chem. Int. Ed. 2022, 61, e202204788, doi: 10.1002/anie.202204788
107. A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies
Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell*
Nat. Commun. 2022, 13, 2366, doi: 10.1038/s41467-022-29691-w
(Protected in patent GB2108355.5)
(Follow-up funding from Scottish Enterprise to support spin-out formation)
106. Activatable fluorophores for imaging immune cell function
Lorena Mendive-Tapia, Marc Vendrell*
Acc. Chem. Res. 2022, 55, 1183-1193, doi: 10.1021/acs.accounts.2c00070
105. Rational design of Phe-BODIPY amino acids as fluorogenic building blocks for peptide-based detection of urinary tract Candida infections
Lorena Mendive-Tapia, David Mendive-Tapia, Can Zhao, Doireann Gordon, Sam Benson, Michael J. Bromley, Wei Wang, Jun Wu, Adelina Kopp, Lutz Ackermann*, Marc Vendrell*
Angew. Chem. Int. Ed. 2022, 61, e202117218, doi: 10.1002/anie.202117218
104. Effective penetration of a novel formulation of bleomycin through ex-vivo skin explants from two different species
Giulia Ferrari, Lisa Y. Pang*, Fabio De Moliner, Marc Vendrell, Richard J.M. Reardon, Andrew J. Higgins, Sunil Chopra, David J. Argyle
Cancers 2022, 14, 1083, doi: 10.3390/cancers14041083
(Featured in Special Issue 'Translational and Comparative Research on Innovative Anti-Cancer Therapies')
103. Rational design and synthesis of large Stokes shift 2,6-sulphur-disubstituted BODIPYs for cell imaging
Abigail E. Reese, Charles Lochenie, Ailsa Geddis, Luana A. Machado, Marcos C. de Souza, Flávia F.C. Marques, Carlos A. de Simone, Marcos M. Gouvêa, Leandro F. Pedrosa, Eufrânio N. da Silva Júnior*, Marc Vendrell*
Chemosensors 2022, 10, 19, doi: 10.3390/chemosensors10010019
(Featured in Special Issue 'Optical Materials: Synthesis and Biological Applications Symposium-XXXVIII Biennial Meeting RSEQ')
102. A bivalent activatable fluorescent probe for screening and intravital imaging of chemotherapy-induced cancer cell death
Nicole Barth, Lorena Mendive-Tapia, Ramon Subiros-Funosas, Ouldouz Ghashghaie, Rodolfo Lavilla, Laura Maiorino, Xue-Yan He, Ian Dransfield, Mikala Egeblad, Marc Vendrell*
Angew. Chem. Int. Ed. 2022, 61, e202113020, doi: 10.1002/anie.202113020
(Apotracker Red licensed and commercialised by BioLegend)
101. Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores
Fabio de Moliner, Ina Biazruchka, Karolina Konsewicz, Sam Benson, Suraj Singh, Jun-Seok Lee,* Marc Vendrell*
Front. Chem. Sci. Eng. 2022, 16, 128-135, doi: 10.1007/s11705-021-2080-8
(Featured in Special Issue on Molecular Sensors and Molecular Logic Gates)
100. Near-infrared fluorescent probes for the detection of cancer-associated proteases
Jamie I. Scott, Qinyi Deng, Marc Vendrell*
ACS Chem. Biol. 2021, 16, 1304-1307, doi: 10.1021/acschembio.1c00223
99. Chemodivergent manganese-catalyzed C–H Activation: modular synthesis of fluorogenic probes
Nikolaos Kaplaneris, Jongwoo Son, Lorena Mendive-Tapia, Adelina Kopp, Nicole Barth, Isaac Maksso, Marc Vendrell,* Lutz Ackermann*
Nat. Commun. 2021, 12, 3389, doi: 10.1038/s41467-021-23462
(Featured in Nature Communications Editors' Highlights: Organic Chemistry and Chemical Biology).
(Featured in Synform, 2021/11, A179–A182, doi: 10.1055/s-0040-1720540)
98. Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
Sam Benson, Fabio de Moliner, Antonio Fernandez, Erkin Kuru, Nicholas Asiimwe, Jun-Seok Lee, Lloyd Hamilton, Dirk Sieger, Isabel Ribeiro Bravo, Abigail Elliot, Yi Feng,* Marc Vendrell*
Nat. Commun. 2021, 12, 2369, doi: 10.1038/s41467-021-22578-2
(Protected in patent WO 2020/187913)
(Featured in 100+ news outlets. Altmetric Score >1000, in the top 5% of all research outputs scored by Altmetric).
97. A palette of minimally-tagged sucrose analogues for real-time Raman imaging of intracellular plant metabolism
Fabio de Moliner, Kirsten Knox, Doireann Gordon, Martin Lee, William J Tipping, Ailsa Geddis, Anke Reinders, John M Ward, Karl Oparka, Marc Vendrell*
Angew. Chem. Int. Ed. 2021, 60, 7637-7642, doi: 10.1002/anie.202016802
(Featured in Synfacts by Dirk Trauner and Anna C. Impastato)
96. A functional chemiluminescent probe for in vivo imaging of Natural Killer cell activity against tumours
Jamie Scott, Sara Gutkin, Ori Green, Emily J. Thompson, Takanori Kitamura,* Doron Shabat,* Marc Vendrell*
Angew. Chem. Int. Ed. 2021, 60, 5699-5703, doi: 10.1002/anie.202011429
(Featured as Hot paper)
95. Genotype-phenotype map of an RNA-ligand complex
Olga Puchta, Grzegorz Sobczyk, Vanessa Smer-Barreto, Hollie Ireland, Marc Vendrell, Diego A. Oyarzún, Janusz M. Bujnicki, Graeme Whyte, Grzegorz Kudla*
BioRxiv 2020, doi: 10.1101/2020.12.17.423258
94. A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
Nicole Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario Shields, Jennifer Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix Goñi, Rodolfo Lavilla, John Marwick, Sonja Vermeren, Adriano Rossi, Mikala Egeblad, Ian Dransfield,* Marc Vendrell*
Nat. Commun. 2020, 11, 4027, doi: 10.1038/s41467-020-17772-7
(Protected in patent WO 2016/207626)
(Apo-15 licensed and commercialised as Apotracker Green by BioLegend)
93. Fluorescent cyclic peptides for cell imaging
Lorena Mendive-Tapia,* Jinling Wang, Marc Vendrell*
Pep. Sci. 2020, e24181, doi: 10.1002/pep2.24181
(TOP downloaded article between 2019 and 2020)
92. Fluorescent amino acids as versatile building blocks for chemical biology
Zhiming Cheng, Erkin Kuru, Amit Sachdeva, Marc Vendrell*
Nat. Rev. Chem. 2020, 4, 275-290, doi: 10.1038/s41570-020-0186-z
(Featured in Front cover)
91. Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
Ramon Subiros-Funosas, Vivian Cheuk Lam Ho, Nicole Barth, Lorena Mendive-Tapia, Morena Pappalardo, Xavier Barril, Ruoyu Ma, Chengbin Zhang, Bin-Zhi Qian, Miquel Sintes, Ouldouz Ghashghaei, Rodolfo Lavilla,* Marc Vendrell*
Chem. Sci. 2020, 11, 1368-1374, doi: 10.1039/C9SC05558D
(Featured among the most popular 2019-2020 analytical chemistry articles)
90. A fluorescent activatable AND-Gate chemokine CCL2 enables in vivo detection of metastasis-associated macrophages
Antonio Fernandez, Emily J. Thompson, Jeffrey W. Pollard, Takanori Kitamura,* Marc Vendrell*
Angew. Chem. Int. Ed. 2019, 58, 16894-16898, doi: 10.1002/ange.201910955
(Featured in 87 news outlets, including Google News). Highest Altmetric Score out of all time in Angewandte Chemie.
89. Assessment of neutrophil apoptosis
Nicole D. Barth, Marc Vendrell, David A. Dorward, Adriano G. Rossi, Ian Dransfield*
Neutrophil: Methods and Protocols (Eds: Mark T. Quinn, Frank DeLeo), Methods in Molecular Biology, 2087, pp. 167-190 (2020), Springer Nature, doi: 10.1007/978-1-0716-0154-9_13
88. Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Peter Brown, RELISH Consortium, Yaoqi Zhou
Database 2019, 1-66, doi: 10.1093/database/baz085
87. BODIPY-labeled cyclobutanes by secondary C(sp3)-H arylations for live-cell imaging
Matteo Virelli, Wei Wang, Rositha Kuniyil, Jun Wu, Giuseppe Zanoni, Antonio Fernandez, Jamie Scott, Marc Vendrell, Lutz Ackermann*
Chem. Eur. J. 2019, 25, 12712-12718, doi: 10.1002/chem.201903461
(Featured as Hot Paper)
86. Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues
Zhi Ming Cheng, Wagner O. Valença, Gleiston G. Dias, Jamie Scott, Nicole D. Barth, Fabio de Moliner, Gabriela B. P. Souza, Richard J. Mellanby, Marc Vendrell,* Eufrânio N. da Silva Junior*
Bioorg. Med. Chem. 2019, 27, 3938-3946, doi: 10.1016/j.bmc.2019.07.017
(Featured in the special issue 'Chemical Immunology')
85. 3D bioprinting of mature bacterial biofilms for antimicrobial resistance drug testing
Evita Ning, Gareth Turnbull, Jon Clarke, Frederic Picard, Philip Riches, Marc Vendrell, Duncan Graham, Alastair Wark, Karen Faulds, Wenmiao Shu*
Biofabrication 2019, 045018, doi: 10.1088/1758-5090/ab37a0
84. In vivo tumor visualization through MRI off-on switching of NaGdF4–CaCO3 nanoconjugates
Zhigao Yi, Zichao Luo, Nicole D. Barth, Xianfu Meng, Hong Liu, Wenbo Bu, Angelo All, Marc Vendrell, Xiaogang Liu*
Adv. Mater. 2019, 1901851, doi: 10.1002/adma.201901851
83. Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model
Ahsan Akram, Nicolaos Avlonitis, Emma Scholefield, Marc Vendrell, Neil McDonald, Tashfeen Aslam, Thomas H. Craven, Calum Gray, David Collie, Andrew Fisher, Paul A. Corris, Timothy Walsh, Christopher Haslett, Mark Bradley, Kevin Dhaliwal*
Sci. Reports 2019, 9, 8422, doi: 10.1038/s41598-019-44804-0
82. A near-infrared probe for in vivo imaging of colorectal lesions in high-risk patients
Stephan Rogalla, Antonio Fernandez, Sanjiv S Gambhir, Marc Vendrell*
Gastroenterology 2019, 156, S376-S377, doi: 10.1016/S0016-5085(19)37785-6
81. SCOTfluors: small, conjugatable, orthogonal and tunable fluorophores for in vivo imaging of cell metabolism
Sam Benson, Antonio Fernandez, Nicole Barth, Fabio de Moliner, Mathew Horrocks, C Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Ziyuan Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell*
Angew. Chem. Int. Ed. 2019, 58, 6911-6915, doi: 10.1002/anie.201900465
(Protected in patent WO 2020/187919)
(Featured as Hot paper and in Angewandte Chemie Press Room)
(Featured in Synfacts by Dirk Trauner and Katharina Hull)
(TOP downloaded article in 2018-2019 Angewandte Chemie)
(Featured in 30+ news outlets. Highest Altmetric Score out of all inputs of similar age in Angewandte Chemie).
(SCOTfluors licensed and commercialised by Tocris)
80. Fluorescent peptides for imaging of fungal cells
Can Zhao, Lorena Mendive-Tapia, Marc Vendrell*
Arch. Biochem. Biophys. 2019, 661, 187-195, doi: 10.1016/j.abb.2018.11.018
(Featured in special issue 'Peptides')
79. Fluorogenic peptides for the detection of programmed cell death
Ramon Subiros-Funosas, Nicole Barth, Jesus Sot, Felix Goni, Lorena Mendive-Tapia, Rodolfo Lavilla, Rodger Duffin, Adriano Rossi, Ian Dransfield, Marc Vendrell*
J. Pep. Sci. 2018, 24, S66-S67
78. Tricarbocyanine N-triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo
Richard Mellanby,* Jamie Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell*
Chem. Sci. 2018, 9, 7261-7270, doi: 10.1039/C8SC00900G
(Protected in patent WO 2020/020905)
(Featured in The Herald, The Scotsman, The Press and Journal, UoE News)
77. Quinone-derived π-extended phenazines as new fluorogenic probes for live-cell imaging of lipid droplets
Fabio de Moliner, Aaron King, Gleiston G. Dias, Guilherme F. de Lima, Carlos A. de Simone, Eufrânio N. da Silva Júnior,* Marc Vendrell*
Front. Chem. 2018, 6, 339, doi: 10.3389/fchem.2018.00339
76. A remote control for switching
Marc Vendrell*
Nat. Chem. Biol. 2018, 14, 749-750, doi: 10.1038/s41589-018-0107-3
75. Multiple multicomponent reactions: unexplored substrates, selective processes and versatile chemotypes in biomedicine
Ouldouz Ghashghaei, Samantha Caputo, Miquel Sintes, Marc Revés, Nicola Kielland, Carolina Estarellas, F. Javier Luque, Anna Aviñó, Ramón Eritja, Ana Serna-Gallego, José Antonio Marrugal-Lorenzo, Jerónimo Pachón, Javier Sánchez-Céspedes, Ryan Treadwell, Fabio de Moliner, Marc Vendrell, Rodolfo Lavilla*
Chem. Eur. J. 2018, 24, 14513-14521, doi: 10.1002/chem.201802877
(Featured as Hot Paper)
74. Probing binding specificity of the sucrose transporter AtSUC2 with fluorescent coumarin glucosides
Fabio de Moliner, Kirsten Knox, Anke Reinders, John Ward, Paul McLaughlin, Karl Oparka,* Marc Vendrell*
J. Exp. Bot., 2018, 69, 2473-2482, doi: 10.1093/jxb/ery075
(Featured in Faculty of 1000)
73. A fluorescent activatable probe for imaging intracellular Mg2+
Ryan Treadwell, Fabio de Moliner, Ramon Subiros-Funosas, Toby Hurd, Kirsten Knox, Marc Vendrell*
Org. Biomol. Chem., 2018, 239-244, doi: 10.1039/c7ob02965a
(Featured in "Chemosensors and Molecular Logic" theme collection)
72. Quinone-based fluorophores for imaging biological processes
Gleiston G. Dias, Aaron King, Fabio de Moliner, Marc Vendrell,* Eufranio N. da Silva Junior*
Chem. Soc. Rev., 2018, 47, 12-27, doi: 10.1039/c7cs00553a
(Featured in the front cover of the 2018 Emerging Investigators Issue)
71. Fluorophore-drug conjugates to unravel the mechanisms of action of therapeutic assets
Antonio Fernandez, Marc Vendrell*
Biochemistry, 2018, 57, 175-176, doi: 10.1021/acs.biochem.7b00889
(Featured in the special issue 'Future of Biochemistry')
70. The 'phagocytic synapse' and clearance of apoptotic cells
Nicole Barth, John A. Marwick, Marc Vendrell, Adriano Rossi, Ian Dransfield*
Frontiers Immunol., 2017, 8, 1708, doi: 10.3389/fimmu.2017.01708
69. Chemical modulation of in vivo macrophage function with subpopulation-specific fluorescent prodrug conjugates
Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng,* Marc Vendrell*
ACS Cent. Sci., 2017, 3, 995-1005, doi: 10.1021/acscentsci.7b00262
68. On the synthesis of quinone-based BODIPY hybrids: new insights on antitumor activity and mechanism of action in cancer cells
Talita B. Gontijo, Rossimiriam P. de Freitas, Flavio S. Emery, Leandro F. Pedrosa, José B. Vieira Neto, Bruno C. Cavalcanti, Claudia Pessoa, Aaron King, Fabio de Moliner, Marc Vendrell*, Eufranio N. da Silva Júnior*
Bioorg. Med. Chem. Lett., 2017, 27, 4446-4456, doi: 10.1016/j.bmcl.2017.08.007
67. Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell imaging
Lorena Mendive-Tapia, Ramon Subiros-Funosas, Can Zhao, Fernando Albericio, Nick D. Read, Rodolfo Lavilla,* Marc Vendrell*
Nat. Protoc., 2017, 12, 1588–1619, doi: 10.1038/nprot.2017.048
66. A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies
Ramon Subiros-Funosas, Lorena Mendive-Tapia, Jesus Sot, John Pound, Nicole Barth, Yaiza Varela, Felix Goñi, Margaret Paterson, Christopher Gregory, Fernando Albericio, Ian Dransfield, Rodolfo Lavilla,* Marc Vendrell*
Chem. Commun., 2017, 53, 945-948, doi: 10.1039/C6CC07879F
(Featured in "Biological Optical Imaging" theme collection)
65. Optical windows for imaging the metastatic tumour microenvironment in vivo
Takanori Kitamura, Jeffrey W. Pollard, Marc Vendrell*
Trends Biotechnol., 2017, 35, 5-8, doi: 10.1016/j.tibtech.2016.05.001
64. Modern synthetic avenues for the preparation of functional fluorophores
Fabio De Moliner, Nicola Kielland, Rodolfo Lavilla,* Marc Vendrell*
Angew. Chem. Int. Ed.., 2017, 56, 3758–3769, doi: 10.1002/anie.201609394
63. Selective detection of apoptotic vesicles with fluorescent Trp-BODIPY labelled cyclic peptides
Ramon Subiros-Funosas, Lorena Mendive-Tapia, John Pound, Jesus Sot, Felix M. Goni, Fernando Albericio, Rodolfo Lavilla, Marc Vendrell*
J. Pep. Sci., 2016, 22, S216.
62. Trp-BODIPY fluorogenic amino acids for minimally invasive labelling of peptides and enhanced live cell fluorescence imaging
Lorena Mendive-Tapia, Ramon Subiros-Funosas, Can Zhao, Ahsan R. Akram, Fernando Albericio, Nick D. Read, Rodolfo Lavilla, Marc Vendrell*
J. Pep. Sci., 2016, 22, S46.
61. Searching for the optimal fluorophore to label antimicrobial peptides
Can Zhao, Antonio Fernandez, Nicolaos Avlonitis, Greetje Vande Velde, Mark Bradley, Nick D. Read,* Marc Vendrell*
ACS Comb. Sci., 2016, 18, 689–696, doi: 10.1021/acscombsci.6b00081
(Featured in front cover)
60. Electrophilic, activation-free fluorogenic reagent for labeling bioactive amines
Miquel Sintes, Fabio De Moliner, David Caballero-Lima, David W. Denning, Nick D. Read, Nicola Kielland,* Marc Vendrell,* Rodolfo Lavilla*
Bioconjugate Chem., 2016, 27, 1430-1434, doi: 10.1021/acs.bioconjchem.6b00245
59. Combinatorial fluorophores for live cell imaging
Marc Vendrell*
Comb. Chem. High Throughput Screen., 2016, 19, 346, doi: 10.2174/138620731905160510213909
58. Red-fluorescent activatable probes for the detection of hydrogen peroxide in living cells
Claudia Garcia-Guzman, Antonio Fernandez, Nicolaos Avlonitis, Mark Bradley, Marc Vendrell*
Comb. Chem. High Throughput Screen., 2016, 19, 353-361, doi: 10.2174/1386207319666160408151313
(Featured in front cover)
57. A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
Liyun Zhang, Jun Cheng Er, Hao Jiang, Xin Li, Zhaofeng Luo, Thomas Ramezani, Yi Feng, Mui Kee Tang, Young-Tae Chang, Marc Vendrell*
Chem. Commun., 2016, 52, 9093-9096, doi: 10.1039/C6CC00095A
(Featured in Chem Comm Emerging Investigators Issue 2016)
56. Smart fluorescent probes for imaging macrophage activity
Antonio Fernandez, Marc Vendrell*
Chem. Soc. Rev., 2016, 45, 1182-1196, doi: 10.1039/C5CS00567A
(Featured in back cover)
55. Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue
Lorena Mendive-Tapia, Can Zhao, Ahsan R. Akram, Sara Preciado, Fernando Albericio, Martin Lee, Alan Serrels, Nicola Kielland, Nick D. Read, Rodolfo Lavilla,* Marc Vendrell*
Nat. Commun., 2016, 7, 10940-10948, doi: 10.1038/ncomms10940
(Protected in patent WO 2016/207626)
(Featured in 10+ news outlets)
54. Structural modifications of the antimicrobial peptide ubiquicidin for pulmonary imaging of bacteria in the alveolar space
Ahsan R. Akram, Nicolaos Avlonitis, Thomas Craven, Marc Vendrell, Neil McDonald, Emma Scholefield, Andrew Fisher, Paul Corris, Chris Haslett, Mark Bradley, Kevin Dhaliwal*
The Lancet, 2016, 387, S17, doi: 10.1016/S0140-6736(16)00404-9
53. Optically detectable antimicrobial peptides enable the immediate detection of bacteria and fungi in the lung
Ahsan R. Akram, Nicolaos Avlonitis, Marc Vendrell, Sunay Chankeshwara, Neil McDonald, Tashfeen Aslam, Emma Scholefield, Tim Walsh, Chris Haslett, Mark Bradley, Kevin Dhaliwal*
Thorax 2015, 70, A2–A3, doi: 10.1136/thoraxjnl-2015-207770.4
52. Multispectral phloem-mobile probes - properties and applications
Michael Knoblauch, Marc Vendrell, Erica de Leau, Andrea Paterlini, Kirsten Knox, Tim J Ross-Elliott, Anke Reinders, Stephen A. Brockman, John Ward, Karl Oparka*
Plant Physiol., 2015, 167, 1211-1220, doi: 10.1104/pp.114.255414
(Featured in Faculty of 1000)
51. A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D1 and D2 dopamine receptors
Anabel Molero, Marc Vendrell,* Jordi Bonaventura, Julian Zachmann, Laura López, Leonardo Pardo, Carme Lluis, Antoni Cortés, Fernando Albericio, Vicent Casadó, Miriam Royo*
Eur. J. Med. Chem., 2015, 97, 173-180, doi: 10.1016/j.ejmech.2015.04.052
50. A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
Yogeswari Chandran, Nam-Young Kang, Sung-Jin Park, Samira Husen Alamudi, Jun-Young Kim, Srikanta Sahu, Dongdong Su, Jungyeol Lee, Marc Vendrell,* Young-Tae Chang*
Bioorg. Med. Chem. Lett., 2015, 25, 4862-4865, doi: 10.1016/j.bmcl.2015.06.037
(Protected in patent WO 2012/173575)
49. Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses
Sung-Jin Park, Hock Chuan Yeo, Nam-Young Kang, Hanjo Kim, Joyce Lin, Hyung-Ho Ha, Marc Vendrell, Jun-Seok Lee, Yogeswari Chandran, Dong-Yup Lee, Seong-Wook Yun, Young-Tae Chang*
Stem Cell Res., 2014, 12, 730-741, doi: 10.1016/j.scr.2014.03.002
48. Multicomponent reactions for de novo synthesis of BODIPY probes: in vivo imaging of phagocytic macrophages
Ana M. Vazquez-Romero, Nicola Kielland, Maria J. Arevalo, Sara Preciado, Richard J Mellanby, Yi Feng, Rodolfo Lavilla, Marc Vendrell*
J. Am. Chem. Soc., 2013, 135, 16018-16021, doi: 10.1021/ja408093p
(Featured in UB News)
47. Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin
Jun Cheng Er, Marc Vendrell, Mui Kee Tang, Duanting Zhai, Young-Tae Chang*
ACS Comb. Sci., 2013, 15, 452–457, doi: 10.1021/co400060b
(Featured in front cover)
46. MegaStokes BODIPY-triazoles as environmentally-sensitive turn-on fluorescent dyes.
Jun Cheng Er, Mui Kee Tang, Chee Geng Chia, Huimin Liew, Marc Vendrell,* Young-Tae Chang*
Chem. Sci., 2013, 4, 2168-2176, doi: 10.1039/C3SC22166K
(Protected in patent WO 2014/104975)
45. Surface enhanced Raman scattering in cancer detection and imaging
Marc Vendrell,* Kaustabh Kumar Maiti,* Kevin Dhaliwal, Young-Tae Chang
Trends Biotechnol., 2013, 31, 249-257, doi: 10.1016/j.tibtech.2013.01.013
(Selected within the Top 25 Hottest Articles in 2013)
44. A fluorescent screening platform for the rapid evaluation of chemicals in reprogramming
Marc Vendrell, Sung-Jin Park, Yogeswari Chandran, Ken Chi-Lik Lee, Hyung-Ho Ha, Nam-Young Kang, Seong-Wook Yun, Young-Tae Chang*
Stem Cell Res., 2012, 9, 185-191, doi: 10.1016/j.scr.2012.06.006
43. Combinatorial Strategies in fluorescent probe development
Marc Vendrell,* Duanting Zhai, Jun Cheng Er, Young-Tae Chang*
Chem. Rev., 2012, 112, 4391-4420, doi: 10.1021/cr200355j
(Within the most read articles from Chemical Reviews in 2012)
42. Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production.
Jaoon Y.H. Kim, Jae Wook Lee, Woo Sirl Lee, Hyung-Ho Ha, Marc Vendrell, Jacqueline T. Bork, Youngsook Lee, Young-Tae Chang*
ACS Comb. Sci., 2012, 14, 395-398, doi: 10.1021/co300007a
41. Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride.
Nicola Kielland, Marc Vendrell, Rodolfo Lavilla,* Young-Tae Chang*
Chem. Commun., 2012, 48, 7401-7403, doi: 10.1039/C2CC32292G
40. Multiplex targeted in vivo detection of cancer using sensitive near-infrared SERS nanotags
Kaustabh Kumar Maiti, U. S. Dinish, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Sung Jin Park, Malini Olivo, Young-Tae Chang*
Nano Today, 2012, 7, 85-93, doi: 10.1016/j.nantod.2012.02.008
39. Synthesis of a novel BODIPY library and its application in the discovery of a fructose sensor
Duanting Zhai, Sung-Chan Lee, Marc Vendrell, Lai Peng Leong, Young-Tae Chang*
ACS Comb. Sci., 2012, 14, 81-84, doi: 10.1021/co200136b
(Most read articles from ACS Comb. Sci. in 2012)
38. Intracellular glutathione detection using MnO2-nanosheet-modified upconversion nanoparticles
Renren Deng, Xiaoji Xie, Marc Vendrell, Young-Tae Chang,* Xiaogang Liu*
J. Am. Chem. Soc., 2011, 133, 20168-20171, doi: 10.1021/ja2100774
37. Diversity-oriented optical imaging probe development
Jun-Seok Lee, Marc Vendrell, Young-Tae Chang*
Curr. Opin. Chem. Biol., 2011, 15, 760-767, doi: 10.1016/j.cbpa.2011.10.007
36. Solid-phase synthesis of BODIPY Dyes and development of an immunoglobulin fluorescent sensor
Marc Vendrell, Gaddamanugu Gopi Krishna, Krishna Kanta Ghosh, Duanting Zhai, Jun-Seok Lee, Qing Zhu, Yin Hoe Yau, Susana Geifman Shochat, Hyori Kim, Junho Chung, Young-Tae Chang*
Chem. Commun., 2011, 47, 8424-8426, doi: 10.1039/C1CC11774B
35. Combinatorial solid-phase synthesis of 6-aryl-1,3,5-triazines via Suzuki coupling
Jae Wook Lee, Hyung-Ho Ha, Marc Vendrell, Jacqueline T. Bork, Young-Tae Chang*
Aust. J. Chem., 2011, 64, 540-544, doi: 10.1071/CH11034
34. Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging
Marc Vendrell, Animesh Samanta, Seong-Wook Yun, Young-Tae Chang*
Org. Biomol. Chem., 2011, 9, 4760-4762, doi: 10.1039/C1OB05519D
(Protected in patent WO 2011/119114)
33. Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer imaging
Animesh Samanta, Kaustabh Kumar Maiti, Kiat-Seng Soh, Xiaojun Liao, Marc Vendrell, U.S. Dinish, Seong-Wook Yun, Ramaswamy Bhuvaneswari, Hyori Kim, Shashi Rautela, Malini Olivo, Junho Chung, Young-Tae Chang*
Angew. Chem. Int. Ed. 2011, 50, 6089-6092, doi: 10.1002/anie.201007841
(Protected in patent WO 2011/119114)
(Featured in A*STAR Research)
32. A photostable near-IR protein labeling dye for in vivo imaging
Animesh Samanta, Marc Vendrell, Seong-Wook Yun, Zhenping Guan, Qing-Hua Xu, Young-Tae Chang*
Chem. Asian J., 2011, 6, 1353-1357, doi: 10.1002/asia.201100041
(Protected in patent WO 2011/119114)
31. Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library
Jun-Seok Lee, Hyeong Kyu Kim, Suihan Feng, Marc Vendrell, Young-Tae Chang*
Chem. Commun., 2011, 47, 2339-2341, doi: 10.1039/C0CC04495D
30. Biotin ergopeptide probes for dopamine receptors
Marc Vendrell, Anabel Molero, Sergio Gonzalez, Kamil Pérez-Capote, Carme Lluis, Peter J. McCormick, Rafael Franco, Antoni Cortés, Vicent Casadó, Fernando Albericio, Miriam Royo*
J. Med. Chem., 2011, 54, 1080-1090, doi: 10.1021/jm101566d
29. Multiplex cancer cell detection by SERS nanotags with triphenylmethine and cyanine Raman reporters
Kaustabh Kumar Maiti, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Young-Tae Chang*
Chem. Commun., 2011, 47, 3514-3516, doi: 10.1039/C0CC05265E
28. Combinatorial search of sensors
Marc Vendrell, Suihan Feng, Young-Tae Chang*
Chemosensors: Principles, Strategies and Applications (Eds: Binghe Wang & Eric V. Anslyn), Wiley-WCH, pp 87-106 (2011), doi: 10.1002/9781118019580.ch6
27. Solid-phase synthesis of dyes and their application as sensors and bioimaging probes
Marc Vendrell, Hyung-Ho Ha, Sung Chan Lee, Young-Tae Chang*
Solid-Phase Organic Synthesis: Concepts, Strategies, and Applications (Eds: Patrick Toy & Yulin Lam), Wiley-WCH, pp. 427-440 (2011), doi: 10.1002/9781118141649.ch14
26. A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors
Aroa Soriano, Marc Vendrell, Sergio Gonzalez, Josefa Mallol, Fernando Albericio, Miriam Royo, Carmen Lluís, Enric I. Canela, Rafael Franco, Antoni Cortés, Vicent Casadó*
J. Pharmacol. Exp. Ther., 2010, 332, 876-885, doi: 10.1124/jpet.109.158824
25. Diversity-oriented fluorescence library approaches for probe discovery and development
Marc Vendrell, Jun-Seok Lee, Young-Tae Chang*
Curr. Opin. Chem. Biol., 2010, 14, 383-389, doi: 10.1016/j.cbpa.2010.02.020
24. A fluorescent rosamine compound selectively stains pluripotent stem cells
Chang-Nim Im, Nam Young Kang, Hyung Ho Ha, Xuezhi Bi, Jae Jung Lee, Sung-Jin Park, Sang Yeon Lee, Marc Vendrell, Yun Kyung Kim, Jun-Seok Lee, Jun Li, Young-Hoon Ahn, Bo Feng, Huck-Hui Ng, Seong-Wook Yun, Young-Tae Chang*
Angew. Chem. Int. Ed., 2010, 49, 7659-7662, doi: 10.1002/anie.201002463
(Featured in Chemical & Engineering News and in A-STAR Research)
23. Development of photostable near-infrared cyanine dyes
Animesh Samanta, Marc Vendrell, Rajkumar Das, Young-Tae Chang*
Chem. Commun., 2010, 46, 7406-7408, doi: 10.1039/C0CC02366C
(Protected in patent WO 2011/119114)
(Featured in Chem Inform)
22. Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors
Marc Vendrell, Aroa Soriano, Vicent Casadó, José Luis Díaz, Rodolfo Lavilla, Enric I. Canela, Carme Lluis, Rafael Franco, Fernando Albericio, Miriam Royo*
ChemMedChem, 2009, 4, 1514-1522, doi: 10.1002/cmdc.200900149
21. Diversity-oriented fluorescence library approach for the discovery of sensors and probes
Jun-Seok Lee, Yun Kyung Kim, Marc Vendrell, Young-Tae Chang*
Mol. Biosyst., 2009, 5, 411-421, doi: 10.1039/B821766C
(Featured in front cover)
20. Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe
Jun-Seok Lee, Nam-young Kang, Yun Kyung Kim, Hyeong Kyu Kim, Animesh Samanta, Suihan Feng, Marc Vendrell, Jung Hwan Park, Young-Tae Chang*
J. Am. Chem. Soc., 2009, 131, 10077-10082, doi: 10.1021/ja9011657
(Featured in JACS Select #10: Supramolecular and Chemical Cascade Approaches to Molecular Sensing).
19. Novel ergopeptides as dual ligands for adenosine and dopamine receptors
Marc Vendrell, Ester Angulo, Vicent Casadó, Carme Lluís, Rafael Franco, Fernando Albericio, Miriam Royo*
J. Med. Chem., 2007, 50, 3062-3069, doi: 10.1021/jm060947x
18. Multiple ligands applied to dopamine and adenosine receptors
Marc Vendrell, Ester Angulo, Aroa Soriano, Anabel Molero, Vicent Casadó, Carme Lluis, Rafael Franco, Sergi Ferre, Fernando Albericio, Miriam Royo*
Proceedings of the 5th Austrian-German-Hungarian-Italian-Polish-Slovenian Joint Meeting on Medicinal Chemistry. (Ed: Danijel Kikelj), 2007.
17. Multicomponent reactions with dihydroazines. Efficient synthesis of a diverse set of pyrido-fused tetrahydroquinolines
Inés Carranco, José Luis Díaz, Óscar Jiménez, Marc Vendrell, Fernando Albericio, Miriam Royo, Rodolfo Lavilla*
J. Comb. Chem., 2005, 7, 33-41, doi: 10.1021/cc049877a
(Most accessed articles in J. Comb. Chem. 2005)
16. N-[Chloro(dimethylamino)methylene]-N-methylmethanaminium chloride (TMUCl Cl), the reagent of choice for the solid-phase synthesis of anilides
Marc Vendrell, Rubén Ventura, Ariel Ewenson, Miriam Royo, Fernando Albericio*
Tet. Lett., 2005, 46, 5383-5386, doi: 10.1016/j.tetlet.2005.05.140
15. A re-evaluation on the use of Rink, BAL and PAL resins and linkers
Francesc Yraola, Rubén Ventura, Marc Vendrell, Aina Colombo, Joan-Carles Fernández, Natalia de la Figuera, Dolors Fernández-Forner, Miriam Royo, Pilar Forns, Fernando Albericio*
QSAR Comb. Sci., 2004, 23, 145-152, doi: 10.1002/qsar.200420013
14. Minimalism applied to a hit to lead program
Marc Vendrell, Rubén Ventura, Fernando Albericio, Rosario González-Muñiz, Laura García de Diego, Cristina Carreño, Antonio Ferrer-Montiel, Miriam Royo*
Peptide Revolution: Genomics, Proteomics & Therapeutics. 18th American Peptide Symposium (Eds: Michael Chorev & Tomi K. Sawyer), 2003.
13. Is it possible to minimize the toxicity of a hit compound without reducing its activity?
Rubén Ventura, Marc Vendrell, Fernando Albericio, Rosario González-Muñiz, Laura García de Diego, Cristina Carreño, Antonio Ferrer-Montiel, Miriam Royo*
Peptide Revolution: Genomics, Proteomics & Therapeutics. 18th American Peptide Symposium (Eds: Michael Chorev & Tomi K. Sawyer), 2003.
PATENTS
12. Antifungal therapeutic and diagnostic compounds in relation to fungal keratitis
Can Zhao, Michael J. Bromley, Marc Vendrell
WO 2023/275537 (granted in EU and USA)
11. Molecular probes for granzyme B detection
Marc Vendrell, Jamie Scott, Doireann Gordon
PCT/GB2022/051477 (Canada, EU, Japan and USA)
10. Small molecule photosensitizers for photodynamic therapy
Marc Vendrell, Sam Benson, Antonio Fernandez, Fabio de Moliner, Nicole Barth
WO 2020/187913 (granted in EU and USA)
9. Small tunable fluorophores for the detection and imaging of biomolecules
Marc Vendrell, Sam Benson, Antonio Fernandez, Fabio de Moliner, Nicole Barth
WO 2020/187919 (granted in EU and USA)
8. Near-infrared chromophores, process of preparation and methods of use
Marc Vendrell, Antonio Fernandez, Richard Mellanby, Jamie Scott, Iris Mair, Claudia Garcia-Guzman, Baljean Dhillon, Pierre Bagnaninchi
WO 2020/020905
7. Molecular probes for detecting gram-negative bacteria in vitro and in vivo
Mark Bradley, Annamaria Lillenkampf, Nicolaos Avlonitis, Marc Vendrell, Neil McDonald, Chris Haslett, Kev Dhaliwal, Tim Walsh
WO 2016/075483 (granted in USA, Japan, Canada, India)
6. Fluorescent polybranched probes for detecting bacteria and/or fungi in vitro and in vivo
Mark Bradley, Annamaria Lillenkampf, Nicolaos Avlonitis, Marc Vendrell, Neil McDonald, Chris Haslett, Kev Dhaliwal, Tim Walsh
WO 2016/075484 (granted in EU, USA, Japan, Canada, India)
5. Fluorogenic amino acid derivatives, process of preparation thereof and methods of use
Marc Vendrell, Ramon Subiros-Funosas, Rodolfo Lavilla, Lorena Mendive-Tapia, Fernando Albericio, Nick Read
WO 2016/207626
4. Megastokes amino-triazolyl-BODIPY compounds and applications to live neuron staining and human serum albumin FA1 drug site probing
Young-Tae Chang, Jun Cheng Er, Cheryl Kit Mun Leong, Seong-Wook Yun, Marc Vendrell, Mui Kee Tang
WO 2014/104975 (granted in China, USA, Japan, EU, Korea, Singapore)
3. Alkylamino BODIPY dyes as selective fluorescent probes for proteins and mouse embryonic stem cells
Young-Tae Chang, Marc Vendrell, Duanting Zhai, Nam-Young Kang, Yogeswari Chandran
WO 2012/173575 (granted in EU, USA)
2. New cyanine dye used for labeling biomolecule e.g. protein and peptide, detecting presence of target in sample and functionalizing nanoparticles in biosensor
Young-Tae Chang, Animesh Samanta, Marc Vendrell, Nam-Young Kang, Kaustabh Kumar Maiti, Kiat-Seng Soh, U.S. Dinish, Malini Olivo, Sung Jin Park
WO 2011/119114 (granted in EU)
1. Pyrrolopyrimidine derivatives as JAK3 inhibitors
Jorge Solanas, Carmen Almansa, Robert Soliva, Montserrat Fontes, Marc Vendrell
WO 2008/119792 (granted in China, Israel, Australia, Canada, Korea, Mexico, EU, India, Russia, USA)